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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveneed for pluripotent stem cells for precise genetic modification in any species became questionable.uniqueness of the pluripotency circuitry across mammalian species may be the main objective for studying pluripotentstem cells in the bovine.

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiateinto cells of the three germ layers, suggesting that PSCs have great potential for basic developmental

Keywords： induced pluripotent stem cells     embryonic stem cells     pig     reprogramming    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germcells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and spatiotemporalinvestigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stemHerein, induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) were transplanted into thetests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stemcells.

Keywords： ischemic stroke     microenvironment     induced pluripotent stem cells (iPSCs)     positron emission tomography    

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityreview will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stemand progenitor cells due to integrating gene transfer vectors, discuss the available assays for predicting

Keywords： gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied fortheir possible use in reproductive medicine, particularly for infertility induced by premature ovariancells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs.

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 5,   Pages 81-87

Abstract:

Differentiated somatic cells can be reprogrammed into induced pluripotentstem cells (iPS) by transduction of a defined transcription factors.Undoubtedly, iPS-cell technology is a great breakthrough of stem cell research field in recent years.However, the present development of pluripotent cells from individual somatic cells just opened up anew door to stem cell research world, much work remains to be done before iPS cells can be considered

Keywords： somatic cells     reprogramming     iPS cells    

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Current Developments in the Stable Production of Human Induced Pluripotent Stem Cells Review

Ikki Horiguchi, Masahiro Kino-oka

Engineering 2021, Volume 7, Issue 2,   Pages 144-152 doi: 10.1016/j.eng.2021.01.001

Abstract:

Induced pluripotent stem cells (iPSCs) are considered to be ideal and promising cell sources for various

Keywords： Induced pluripotent stem cell     Cell manufacturing     Expansion     Filling     Freezing    

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SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 81-92 doi: 10.15302/J-FASE-2017180

Abstract: alternative splicing variants, which are differentially expressed and has a key role in maintaining pluripotentstem cells.However, the molecular features and function of SALL4 have not been well elucidated in porcine inducedpluripotent stem cells (piPSCs).pluripotent genes, when SALL4B significantly promoted OCT4 expression.

Keywords： OTX2     pluripotency     pig     SALL4     transcription regulation    

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Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 185-191 doi: 10.1007/s11684-007-0035-1

Abstract: In this study, we further isolated pluripotent stem cells from human fetal heart, liver, muscle, lungIt was found that the phenotype of the culture-expanded pluripotent stem cells from different fetal tissuesMore importantly, culture-expanded pluripotent stem cells from all these fetal tissues were able to differentiateThese pluripotent stem cells with characteristics similar to fetal BM-derived Flk1CD34 PPSCs can be selectedIn addition, as fetal BM-derived Flk1CD34 PPSCs, these pluripotent stem cells from different fetal tissues

Keywords： endothelial     phenomenon     ectodermal     Flk1CD34 postembryonic     irradiated non-obese    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalIn this study, telomerase activity was measured and compared in breast cancer stem cells and non-stemThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.As the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress ofstem cell therapy.By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: an emerging interdisciplinary field of research that uses several technological approaches including stemcells to repair tissues.Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest overmechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cellsinto osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells

Keywords： mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

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Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

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Title Author Date Type Operation

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Journal Article

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Journal Article

Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Journal Article

Current Developments in the Stable Production of Human Induced Pluripotent Stem Cells

Ikki Horiguchi, Masahiro Kino-oka

Journal Article

SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Journal Article

Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Journal Article